Cancer consists of a large body of diseases with many possible causes. Although most cancer cells develop over a lifetime due to gradual genetic changes, a genetic predisposition to some cancers can be inherited from birth. If a specific form of cancer seems to run in your family, you should visit an oncologist to evaluate your risk. Below are some common cancers linked to inherited mutations.

A Guide to Common Hereditary Cancers

1. Breast Cancer

Anyone can develop breast cancer, though the primary risk factors are being a woman over the age of 50. In hereditary cases, breast cancer tends to develop at a younger age. A family history of breast cancer is known as Hereditary Breast and Ovarian Cancer (HBOC) syndrome. HBOC is typically caused by a mutation in the BRCA1 or BRCA2 gene.

2. Colorectal Cancer

Inheriting Lynch syndrome, or hereditary non-polyposis colorectal cancer (HNCC), greatly increases an individual’s risk of getting colorectal cancer. As with breast cancer patients, most people with Lynch syndrome develop colorectal cancer at a younger age than that of the general population. HNCC can be the result of a mutation in one of many mismatch repair genes, including MLH1, MSH2, MSH6, PMS1, and PMS2.

3. Endometrial Cancer

Endometrial cancer comes from the out-of-control growth of cells in the lining of the uterus. Having Lynch syndrome can increase the chances of developing endometrial cancer in addition to colorectal cancer. Other mutated genes linked to a higher risk of endometrial cancer include EPCAM, CHEK2, STK11, and TP53. 

4. Prostate Cancer

Men with BRCA1 or BRCA2 genetic mutations are at a higher risk of developing both breast and prostate cancer than those without a family history. Mutations can occur on either gene, but these types of cancers are more common in the BRCA2 gene. Those with CHEK2, MLH1, MLH2, MLH6, ATM, and other inherited mutations may also be at risk.

5. Leukemia

A cancer of the body’s blood-forming tissues, leukemia can sometimes be the result of a rare inherited condition called Li-Fraumeni syndrome. It is most often caused by a TP53 genetic mutation. This is a tumor suppressing gene that normally helps prevent the growth of abnormal cells.

If you have a family history of cancer, you may benefit from regular screenings with the professionals at Tennessee Plateau Oncology – Dirk Davidson, M.D. This team of skilled Crossville oncologists has a combined 100 years of experience treating cancer and blood disorders. This local cancer treatment center makes use of cutting-edge technology, patient education, and personalized care to help guide you through your journey, no matter what type of cancer you have. Visit their website for more information about services. To schedule an appointment with a knowledgeable and attentive oncologist, call (931) 484-7596.